Sunday, January 6, 2013

Simultaneous lymph node involvement by Castleman disease and Kaposi sarcoma.

Simultaneous lymph node involvement by Castleman disease and Kaposi sarcoma.



Instituto de Pesquisa Clínica Evandro Chagas (IPE), Fiocruz Rio de Janeiro (RJ), Brazil.


Both multicentric Castleman disease and Kaposi sarcoma are more frequently observed in HIV infected patients. The coexistence of these Human herpes virus 8 related lesions, in the same tissue, has been observed, but literature reports are scant. On the other hand, the expression of HHV-8-LANA-1 is easily demonstrable by immunohistochemistry. This has been shown to be a powerful tool for the diagnosis of these entities. The aim of this report is to communicate our experience with a case of multicentric Castleman disease occurring in the setting of HIV infection, which demonstrated microscopic Kaposi sarcoma in the same lymph node during the pathological work-up.

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